Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.47 |
| ▸ | GSK3B | P49841 | 8/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | CDK1 | P06493 | 4/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314457 | 1.00 | CDK4 (0.47) | CDK4GSK3BCDK2CDK1CCNB1 | |
| SCHEMBL5313486 | 0.88 | CDK4 (0.48) | CDK4GSK3BCDK2CDK1CCNB1 | |
| SCHEMBL5313478 | 0.88 | CDK4 (0.48) | CDK4GSK3BCDK2CDK1CCNB1 | |
| SCHEMBL5311802 | 0.82 | PIK3C3 (0.58) | CDK4GSK3BCDK2CDK1CCNB1 | |
| SCHEMBL5311805 | 0.82 | PIK3C3 (0.58) | CDK4GSK3BCDK2CDK1CCNB1 | |
| SCHEMBL5315804 | 0.79 | CDK4 (0.47) | CDK4GSK3BCDK2CDK1CCNB1 | |
| SCHEMBL5315799 | 0.79 | CDK4 (0.47) | CDK4GSK3BCDK2CDK1CCNB1 | |
| SCHEMBL5336071 | 0.78 | CDK4 (0.51) | CDK4GSK3BCDK2MAPK8MAPK9 | |
| SCHEMBL5336074 | 0.78 | CDK4 (0.51) | CDK4GSK3BCDK2MAPK8MAPK9 | |
| SCHEMBL8227614 | 0.76 | MAPK9 (0.57) | CDK4GSK3BCDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |