Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.51 |
| ▸ | GSK3B | P49841 | 6/20 | 0.51 |
| ▸ | IKBKB | O14920 | 5/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336074 | 1.00 | CDK4 (0.51) | CDK4GSK3BIKBKBMAPK8MAPK9 | |
| SCHEMBL8235105 | 0.82 | CDK4 (0.51) | CDK4GSK3BIKBKBMAPK8MAPK9 | |
| SCHEMBL5311802 | 0.79 | PIK3C3 (0.58) | CDK4GSK3BMAPK8MAPK9PIK3C3 | |
| SCHEMBL5311805 | 0.79 | PIK3C3 (0.58) | CDK4GSK3BMAPK8MAPK9PIK3C3 | |
| SCHEMBL5314460 | 0.78 | CDK4 (0.47) | CDK4GSK3BIKBKBMAPK8MAPK9 | |
| SCHEMBL5314457 | 0.78 | CDK4 (0.47) | CDK4GSK3BIKBKBMAPK8MAPK9 | |
| SCHEMBL5315799 | 0.76 | CDK4 (0.47) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL5315804 | 0.76 | CDK4 (0.47) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL8227614 | 0.75 | MAPK9 (0.57) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL5312512 | 0.75 | MAPK8 (0.49) | CDK4GSK3BMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |