SCHEMBL5314508

SCHEMBL5314508

CS(=O)(=O)c1ccc(-c2cc(C(F)F)cn2-c2ccc(F)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 18/20 0.60
PTGS1 P23219 6/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7215890 0.87 PTGS2 (0.60) PTGS2PTGS1
SCHEMBL5314070 0.83 PTGS2 (0.66) PTGS2PTGS1
SCHEMBL5312684 0.83 PTGS2 (0.66) PTGS2PTGS1
SCHEMBL5311508 0.79 PTGS2 (0.60) PTGS2PTGS1
SCHEMBL5309149 0.78 PTGS2 (0.63) PTGS2PTGS1
SCHEMBL27481215 0.75 CHRNA7 (0.37) PTGS2PTGS1
SCHEMBL5309608 0.75 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL8502465 0.75 PTGS2 (0.58) PTGS2PTGS1
SCHEMBL5314063 0.75 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL5308875 0.75 CHRNA7 (0.63) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0799823-B1 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses DAIICHI SANKYO CO LTD (JP) 2007-10-31 EP disclosed
US-RE39420-E1 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses SANKYO COMPANY, LIMITED (JP) 2006-12-05 US disclosed
CN-1151126-C 1, 2-diphenylpyrrole derivatives, their preparation and their therapeutic uses ������������ʽ���� 2004-05-26 CN disclosed
US-5908858-A OSTEOPOROSIS; LEUKOTRIENE INHIBITOR SANKYO COMPANY, LIMITED (JP) 1999-06-01 US disclosed
CN-1168372-A 1, 2-diphenylpyrrole derivatives, their preparation and their therapeutic uses SANKYO CO (JP) 1997-12-24 CN disclosed
EP-0799823-A1 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses SANKYO COMPANY LIMITED (JP) 1997-10-08 EP disclosed