Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 6/20 | 0.51 |
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336551 | 0.87 | EPHX2 (0.52) | KCNH2HTR2AHTR2CCD274EPHX2 | |
| SCHEMBL5319119 | 0.84 | CD274 (0.49) | KCNH2CD274DRD2EPHX2NAMPT | |
| SCHEMBL5318987 | 0.83 | CD274 (0.56) | KCNH2CD274DRD2EPHX2NAMPT | |
| SCHEMBL5314456 | 0.83 | EPHX2 (0.52) | CD274EPHX2CYP2C9CYP2C19CYP2J2 | |
| SCHEMBL3131750 | 0.82 | KCNH2 (0.65) | KCNH2HTR2AHTR2CDRD2 | |
| SCHEMBL5318392 | 0.81 | CD274 (0.58) | KCNH2CD274DRD2EPHX2NAMPT | |
| SCHEMBL5317478 | 0.81 | CCR3 (0.54) | CD274DRD2NAMPT | |
| SCHEMBL5316201 | 0.80 | CD274 (0.51) | KCNH2CD274DRD2EPHX2NAMPT | |
| SCHEMBL5315274 | 0.80 | CD274 (0.53) | KCNH2CD274DRD2EPHX2NAMPT | |
| SCHEMBL5314744 | 0.79 | CD274 (0.54) | KCNH2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |