Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.72 |
| ▸ | MEN1 | O00255 | 8/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 5/20 | 0.72 |
| ▸ | RAB9A | P51151 | 4/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | GALR3 | O60755 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316011 | 0.87 | MEN1 (0.64) | KMT2AMEN1MAPK1LMNARAB9A | |
| SCHEMBL5315209 | 0.86 | KMT2A (0.69) | KMT2AMEN1MAPK1LMNARAB9A | |
| SCHEMBL540760 | 0.83 | HRH3 (0.65) | KMT2AMAPK1RAB9ANPC1KDM4E | |
| SCHEMBL4922787 | 0.82 | NPC1 (0.65) | KMT2AMAPK1LMNARAB9ANPC1 | |
| SCHEMBL5314882 | 0.81 | HDAC3 (0.65) | KMT2AMEN1LMNAPOLBKDM4E | |
| SCHEMBL3920768 | 0.77 | HRH3 (0.56) | KMT2AMEN1MAPK1LMNARAB9A | |
| SCHEMBL5559651 | 0.76 | ALDH1A1 (0.64) | KMT2AMAPK1LMNAPOLBALDH1A1 | |
| SCHEMBL4743824 | 0.75 | KMT2A (0.58) | KMT2AMEN1MAPK1LMNARAB9A | |
| SCHEMBL11926732 | 0.74 | ALDH1A1 (0.73) | KMT2AMEN1MAPK1LMNARAB9A | |
| SCHEMBL4725306 | 0.74 | POLB (0.54) | KMT2AMEN1MAPK1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067994-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| US-20070135431-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070135431-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070135431-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC (US) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135431-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | HDAC6, HDAC1, HDAC3 | KMT2A 52/4885MEN1 4108/4885MAPK1 1811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.