Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725768 | 0.87 | MAPT (0.51) | MAPTKMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4728012 | 0.86 | CES1 (0.48) | MAPTALDH1A1LMNASMN1; SMN2DRD3 | |
| SCHEMBL4727610 | 0.86 | UCHL1 (0.51) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4729811 | 0.86 | ALDH1A1 (0.50) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4726510 | 0.86 | CNR2 (0.49) | MAPTHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL4728036 | 0.84 | DRD3 (0.42) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4726548 | 0.84 | CRHBP (0.48) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4725454 | 0.84 | DRD3 (0.57) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4730511 | 0.84 | FFAR1 (0.44) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4728980 | 0.84 | DRD3 (0.42) | POLBMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | disclosed |