Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375164 | 0.88 | KDM4E (0.54) | PTGER4POLBALDH1A1NPSR1MAPT | |
| SCHEMBL5317398 | 0.81 | ITK (0.49) | MAPT | |
| SCHEMBL5320026 | 0.80 | PTGER4 (0.47) | PTGER4POLBHCAR3ALDH1A1NPSR1 | |
| SCHEMBL5318216 | 0.79 | ITK (0.43) | PTGER4POLBALDH1A1NPSR1MAPT | |
| Water SCHEMBL5319087 | 0.79 | PTGER4 (0.46) | PTGER4POLBHCAR3ALDH1A1NPSR1 | |
| SCHEMBL5319931 | 0.79 | HRH3 (0.49) | PTGER4POLBALDH1A1NPSR1MAPT | |
| SCHEMBL5318236 | 0.78 | ITK (0.49) | — | |
| SCHEMBL2687107 | 0.76 | KMT2A (0.60) | PTGER4HCAR3ALDH1A1KDM4EKMT2A | |
| SCHEMBL5317414 | 0.75 | HCAR3 (0.56) | PTGER4HCAR3ALDH1A1MAPTGAA | |
| SCHEMBL4258690 | 0.74 | HDAC6 (0.53) | POLBHCAR3GAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |