Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318392 | 0.91 | CD274 (0.58) | CD274CCR3EPHX2CHRM4DRD2 | |
| SCHEMBL5315942 | 0.89 | CD274 (0.56) | CD274CCR3EPHX2CHRM4DRD2 | |
| SCHEMBL5314550 | 0.87 | CD274 (0.53) | CD274CCR3EPHX2CHRM4DRD2 | |
| SCHEMBL5318987 | 0.87 | CD274 (0.56) | CD274CCR3EPHX2CHRM4DRD2 | |
| SCHEMBL5316471 | 0.87 | CD274 (0.56) | CD274CCR3EPHX2CHRM4DPP4 | |
| SCHEMBL5317478 | 0.86 | CCR3 (0.54) | CD274CCR3CHRM4DRD2DRD3 | |
| SCHEMBL5314465 | 0.86 | CD274 (0.51) | CD274CCR3EPHX2CHRM4DRD2 | |
| SCHEMBL5315964 | 0.85 | CD274 (0.54) | CD274CCR3CHRM4DRD2DRD3 | |
| SCHEMBL5314744 | 0.85 | CD274 (0.54) | CD274CCR3KCNH2MKNK1MKNK2 | |
| SCHEMBL5318512 | 0.84 | CCR3 (0.57) | CD274CCR3CHRM4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |