Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | TPH1 | P17752 | 6/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228408 | 0.87 | CA12 (0.44) | CA12CA1CA2CA9SCN5A | |
| SCHEMBL8252393 | 0.80 | S1PR1 (0.56) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL15307622 | 0.80 | L3MBTL1 (0.58) | CA12CA1CA2CA9L3MBTL1 | |
| Hydrochloric Acid SCHEMBL21683293 | 0.79 | L3MBTL1 (0.56) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL31524131 | 0.78 | TPH1 (0.67) | PLK1TPH1LMNATSHRNFKB1 | |
| SCHEMBL19941493 | 0.77 | CA12 (0.54) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL19112036 | 0.77 | PLK1 (0.49) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL13415301 | 0.76 | L3MBTL1 (0.69) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL14210018 | 0.75 | PLK1 (0.55) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL8436680 | 0.75 | MAPT (0.61) | CA12CA1CA2CA9L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771449-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-04-11 | — | — | EP | claimed |
| WO-2006011043-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-02-02 | — | — | WO | claimed |