Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PLD1 | Q13393 | 3/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PLD2 | O14939 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317369 | 0.95 | KCNH2 (0.60) | KCNH2CD274HRH2HRH1PRKAA2 | |
| SCHEMBL5314744 | 0.91 | CD274 (0.54) | KCNH2CD274HRH2HRH1PRKAA2 | |
| SCHEMBL5316918 | 0.86 | KCNA5 (0.54) | KCNH2CD274HRH2HRH1KCNA5 | |
| SCHEMBL5319119 | 0.83 | CD274 (0.49) | KCNH2CD274PLD1RAB9AKDM1A | |
| SCHEMBL4134193 | 0.82 | KCNH2 (0.53) | KCNH2CD274HRH2HRH1KCNA5 | |
| SCHEMBL5314554 | 0.79 | KCNH2 (0.53) | KCNH2CD274 | |
| SCHEMBL5318392 | 0.78 | CD274 (0.58) | KCNH2CD274 | |
| SCHEMBL4137801 | 0.78 | KCNH2 (0.59) | KCNH2HRH2HRH1 | |
| SCHEMBL2966798 | 0.78 | KCNH2 (0.53) | KCNH2HRH2HRH1KCNA5 | |
| SCHEMBL5316201 | 0.77 | CD274 (0.51) | KCNH2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |