Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914244 | 0.88 | CLK4 (0.46) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5914240 | 0.88 | CLK4 (0.46) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5914185 | 0.84 | CLK4 (0.39) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5262307 | 0.84 | CLK4 (0.39) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5913924 | 0.81 | CLK4 (0.43) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5913917 | 0.81 | CLK4 (0.43) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5913862 | 0.78 | CFD (0.39) | CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL5914160 | 0.76 | AURKA (0.36) | MAPK14AURKACDK4 | |
| SCHEMBL5914416 | 0.76 | MAPK14 (0.40) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5914418 | 0.76 | MAPK14 (0.40) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |