Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 13/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.45 |
| ▸ | USP2 | O75604 | 5/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914244 | 1.00 | CLK4 (0.46) | CLK4CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5913917 | 0.92 | CLK4 (0.43) | CLK4CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5913924 | 0.92 | CLK4 (0.43) | CLK4CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5316304 | 0.88 | CLK4 (0.37) | CLK4CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5914418 | 0.87 | MAPK14 (0.40) | CLK4CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5914416 | 0.87 | MAPK14 (0.40) | CLK4CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5913862 | 0.86 | CFD (0.39) | CYP1A2CYP3A4CYP2C19CYP2D6LMNA | |
| SCHEMBL5318168 | 0.86 | CLK4 (0.37) | CLK4CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5318166 | 0.86 | CLK4 (0.37) | CLK4CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5914185 | 0.85 | CLK4 (0.39) | CLK4CYP1A2CYP3A4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | MAPT, MYLK2, IAPP | CLK4 2319/4885CYP1A2 1159/4885CYP3A4 1290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.