Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11347630 | 0.82 | MAPT (0.41) | CRHBPCRHR2KEAP1NFE2L2MEN1 | |
| SCHEMBL5107697 | 0.82 | MEN1 (0.35) | CRHBPCRHR2KEAP1NFE2L2MEN1 | |
| SCHEMBL6680537 | 0.79 | NPY5R (0.47) | MEN1POLBKMT2ANPC1ATM | |
| SCHEMBL6365368 | 0.77 | POLB (0.49) | MEN1POLBMMP14BLMCASP6 | |
| SCHEMBL6365200 | 0.76 | NPC1 (0.35) | CRHBPCRHR2KEAP1NFE2L2MEN1 | |
| SCHEMBL6679140 | 0.76 | IDO1 (0.38) | CRHBPCRHR2KEAP1NFE2L2MEN1 | |
| SCHEMBL6676039 | 0.74 | RAD52 (0.48) | MEN1POLBMMP14BLMCASP6 | |
| SCHEMBL6679187 | 0.74 | IDO1 (0.37) | CRHBPCRHR2KEAP1NFE2L2MEN1 | |
| SCHEMBL5107999 | 0.73 | KMT2A (0.49) | MEN1KMT2ANPC1MAPT | |
| SCHEMBL6673522 | 0.73 | ALDH1A1 (0.36) | MEN1POLBMMP14BLMCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846392-A2 | HETEROCYCLIC TRIAZINES AS HYPOXIC SELECTIVE PROTEIN KINASE INHIBITORS | Sentinel Oncology Limited (GB) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006131835-A2 | HETEROCYCLIC TRIAZINES AS HYPOXIC SELECTIVE PROTEIN KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2006-12-14 | — | — | WO | disclosed |