⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14326907 | 0.75 | — | — | |
| SCHEMBL124562 | 0.72 | — | — | |
| SCHEMBL5315347 | 0.70 | — | — | |
| SCHEMBL8709485 | 0.70 | — | — | |
| SCHEMBL4500250 | 0.69 | HCAR2 (0.51) | — | |
| SCHEMBL4503649 | 0.69 | HCAR2 (0.51) | — | |
| SCHEMBL6113650 | 0.68 | — | — | |
| SCHEMBL29388308 | 0.68 | KDM4E (0.33) | — | |
| SCHEMBL13143012 | 0.68 | TSHR (0.35) | — | |
| SCHEMBL5880765 | 0.65 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347033-A1 | HYDROXY AND (HALO)ALKOXY SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2024-04-10 | — | — | EP | disclosed |
| US-20230357254-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-09 | — | — | US | disclosed |
| US-11702422-B2 | Imidazopyridazines as modulators of IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-18 | — | — | US | disclosed |
| US-11702422-B2 | Imidazopyridazines as modulators of IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-18 | — | — | US | disclosed |
| US-11691979-B2 | Imidazopyridazines as modulators of IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-04 | — | — | US | disclosed |
| EP-4143195-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | Janssen Pharmaceutica NV (BE) | 2023-03-08 | — | — | EP | disclosed |
| WO-2022256842-A1 | HYDROXY AND (HALO)ALKOXY SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2021222404-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | JANSSEN BIOTECH, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| US-9758509-B2 | Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-9758509-B2 | Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| EP-0563328-B1 | Tc(III)-99m MYOCARDIAL IMAGING AGENTS AND METHOD OF USE | MALLINCKRODT MEDICAL INC (US) | 1999-06-30 | — | — | EP | disclosed |
| CN-1194580-A | Ketone derivatives and medical use thereof | TORAY INDUSTRIES (JP) | 1998-09-30 | — | — | CN | disclosed |
| EP-0841063-A1 | KETONE DERIVATIVES AND MEDICINAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1998-05-13 | — | — | EP | disclosed |
| EP-0563328-A1 | ?99m Tc(III) MYOCARDIAL IMAGING AGENTS AND METHOD OF USE | MALLINCKRODT MEDICAL, INC. (US) | 1993-10-06 | — | — | EP | disclosed |
| US-5242945-A | Antiinflammatory | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |
| EP-0508690-A1 | Tetronic and thiotetronic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-10-14 | — | — | EP | disclosed |
| WO-1992011040-A2 | 99mTc(III) MYOCARDIAL IMAGING AGENTS AND METHOD OF USE | MALLINCKRODT MEDICAL, INC. (US) | 1992-07-09 | — | — | WO | disclosed |
| US-5112595-A | Diaminoalkyldifuranones and phosphine ligands with technetium for imaging | MALLINCKRODT MEDICAL, INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5112594-A | Diaminoalkyldifuranones and phosphine ligands with technetium for imaging | MALLINCKRODT MEDICAL, INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-4996227-A | Administering nontoxic antitumor agents | UNIVERSITY OF CINCINNATI (US) | 1991-02-26 | — | — | US | disclosed |