Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.31 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739003 | 0.80 | KIF11 (0.41) | KIF11 | |
| SCHEMBL6165008 | 0.79 | TAAR1 (0.38) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7846363 | 0.69 | KIF11 (0.31) | KIF11 | |
| SCHEMBL7425572 | 0.68 | — | — | |
| SCHEMBL5491761 | 0.68 | — | — | |
| SCHEMBL6184942 | 0.68 | NR1H2 (0.36) | OPRK1 | |
| SCHEMBL8827814 | 0.68 | TAAR1 (0.38) | OPRM1KCNH2OPRD1OPRK1 | |
| SCHEMBL9555492 | 0.68 | KIF11 (0.37) | GRIN2DGRIN1GRIN2AGRIN2BGRIN2C | |
| SCHEMBL7691758 | 0.67 | — | — | |
| SCHEMBL4729192 | 0.66 | OPRK1 (0.40) | OPRM1OPRD1OPRK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819121-B1 | TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES | SCHERING CORP (US) | 2007-05-30 | — | — | EP | disclosed |
| US-6214827-B1 | ANTITUMOR, ANTICANCER AGENTS | SCHERING CORPORATION | 2001-04-10 | — | — | US | disclosed |