Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.49 |
| ▸ | MME | P08473 | 2/20 | 0.48 |
| ▸ | CTSD | P07339 | 2/20 | 0.48 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316454 | 1.00 | BACE1 (0.49) | BACE1BACE2MMECTSDTASP1 | |
| SCHEMBL5310645 | 0.92 | KEAP1 (0.46) | BACE1BACE2MMECTSDTASP1 | |
| SCHEMBL5310633 | 0.92 | KEAP1 (0.46) | BACE1BACE2MMECTSDTASP1 | |
| SCHEMBL29593152 | 0.92 | MME (0.53) | BACE1BACE2MMECTSDTASP1 | |
| SCHEMBL5314389 | 0.90 | KEAP1 (0.44) | BACE1BACE2MMECTSDTASP1 | |
| SCHEMBL5314387 | 0.90 | KEAP1 (0.44) | BACE1BACE2MMECTSDTASP1 | |
| SCHEMBL30881180 | 0.88 | FOLH1 (0.52) | BACE1BACE2CTSDGRIN2DGRIN3B | |
| SCHEMBL31480017 | 0.88 | BACE1 (0.51) | BACE1BACE2CTSDGRIN2DGRIN3B | |
| SCHEMBL31341152 | 0.87 | FOLH1 (0.53) | BACE1BACE2CTSDFOLH1 | |
| SCHEMBL5316516 | 0.86 | BACE1 (0.49) | BACE1BACE2MMECTSDTASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056047-A2 | ANTIBODIES, ASSAYS AND KITS TO QUANTITATE CARTILAGE DESTRUCTION | ARTICULAR ENGINEERING, LLC. (US) | 2007-05-18 | — | — | WO | claimed |
| US-20070099246-A1 | Antibodies, assays and kits to quantitate cartilage destruction | SANDY JOHN D | 2007-05-03 | — | — | US | claimed |
| WO-2007056047-A2 | ANTIBODIES, ASSAYS AND KITS TO QUANTITATE CARTILAGE DESTRUCTION | ARTICULAR ENGINEERING, LLC. (US) | 2007-05-18 | — | — | WO | disclosed |
| US-20070099246-A1 | Antibodies, assays and kits to quantitate cartilage destruction | SANDY JOHN D | 2007-05-03 | — | — | US | disclosed |