Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.51 |
| ▸ | CCND1 | P24385 | 4/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 5/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30433945 | 1.00 | CDK4 (0.51) | CDK4CCND1GSK3BPARP1PDPK1 | |
| SCHEMBL29973094 | 0.74 | SMN1; SMN2 (0.44) | CDK4CCND1PARP1PDPK1CA12 | |
| SCHEMBL28626976 | 0.74 | SMN1; SMN2 (0.44) | CDK4CCND1PARP1PDPK1CA12 | |
| SCHEMBL27215626 | 0.74 | CASP3 (0.41) | CDK4CCND1PARP1PDPK1CA12 | |
| SCHEMBL459050 | 0.73 | KMT2A (0.44) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL1103721 | 0.73 | MEN1 (0.44) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL16895263 | 0.73 | DNMT1 (0.46) | SMN1; SMN2KDM4EGPR3MEN1MAPT | |
| SCHEMBL29641696 | 0.73 | KMT2A (0.44) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL8874682 | 0.73 | KDM4E (0.42) | CDK4CCND1PARP1PDPK1CA12 | |
| SCHEMBL5469529 | 0.72 | NPC1 (0.48) | GSK3BSMN1; SMN2KDM4EMAPTCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112358479-B | Synthesis method of pyrrolo [3,4-c ] quinoline-1, 3-dione compound | 西北师范大学 | 2023-06-16 | — | — | CN | claimed |
| CN-112358479-B | Synthesis method of pyrrolo [3,4-c ] quinoline-1, 3-dione compound | 西北师范大学 | 2023-06-16 | — | — | CN | disclosed |
| CN-112358479-B | Synthesis method of pyrrolo [3,4-c ] quinoline-1, 3-dione compound | 西北师范大学 | 2023-06-16 | — | — | CN | disclosed |
| CN-112358479-A | Synthesis method of pyrrolo [3,4-c ] quinoline-1, 3-diketone compound | 西北师范大学 | 2021-02-12 | — | — | CN | disclosed |
| CN-103172587-A | Benzisothiazole-3-ketone-2-amide compound with Caspase-3 inhibiting activity | TIANJIN INT JOINT ACADEMY BIOTECHNOLOGY & MEDICINE | 2013-06-26 | — | — | CN | disclosed |
| CN-103169700-A | Application of 1,2-benzisothiazole-3-ketone compound in inhibiting caspase-3 activity | TIANJIN INT JOINT ACADEMY BIOTECHNOLOGY & MEDICINE | 2013-06-26 | — | — | CN | disclosed |
| US-20070191337-A1 | Annellated carbamyl-aza-heterocyclic compounds, a focused library, pharmaceutical compositions, and methods of preparing the same | IVASHCHENKO ALEXANDER | 2007-08-16 | — | — | US | disclosed |
| EP-1746100-A1 | ANNELATED CARBAMOYLASE-HETEROCYCLES, FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THE PRODUCTION THEREOF | "Chemical diversity Research Institute", Ltd. (RU) | 2007-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191337-A1 | Annellated carbamyl-aza-heterocyclic compounds, a focused library, pharmaceutical compositions, and methods of preparing the same | ADORA2A, CDK20, CDK2 | CDK4 14/4885CCND1 23/4885GSK3B 4546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.