Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111475 | 0.85 | TSHR (1.00) | TSHRALDH1A1KDM4EMAPTPKM | |
| SCHEMBL8746347 | 0.85 | TSHR (1.00) | TSHRALDH1A1KDM4EMAPTPKM | |
| SCHEMBL3201023 | 0.85 | TSHR (1.00) | TSHRALDH1A1KDM4EMAPTPKM | |
| SCHEMBL8875725 | 0.85 | TSHR (1.00) | TSHRALDH1A1KDM4EMAPTPKM | |
| SCHEMBL14365934 | 0.85 | TSHR (1.00) | TSHRALDH1A1KDM4EMAPTPKM | |
| SCHEMBL14393160 | 0.85 | TSHR (1.00) | TSHRALDH1A1KDM4EMAPTPKM | |
| SCHEMBL7143000 | 0.84 | TSHR (0.74) | TSHRALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL3890951 | 0.84 | TSHR (0.74) | TSHRALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL2210689 | 0.84 | TSHR (0.79) | TSHRALDH1A1MAPTGAAKMT2A | |
| SCHEMBL20702809 | 0.84 | TSHR (0.68) | TSHRALDH1A1KDM4EMAPTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |