Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111475 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL3201023 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL8875725 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL14393160 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL14365934 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL2210689 | 0.88 | TSHR (0.79) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| Phenyl Propionic Acid SCHEMBL28865692 | 0.87 | TSHR (0.76) | TSHRALDH1A1 | |
| SCHEMBL14967814 | 0.87 | TSHR (0.77) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL6751902 | 0.85 | TSHR (0.74) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL5316941 | 0.85 | TSHR (0.74) | TSHRCYP2C19MEN1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200355-A1 | Method for Preparing Optically Pure (-)-Clausenamide Compound | INSTITUTE OF CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN) | 2014-07-17 | — | — | US | disclosed |
| US-20140200355-A1 | Method for Preparing Optically Pure (-)-Clausenamide Compound | INSTITUTE OF CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN) | 2014-07-17 | — | — | US | disclosed |
| EP-0654026-B1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1997-02-19 | — | — | EP | disclosed |
| US-5576438-A | LIPOXYGENASE INHIBITORS; ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktiesel Skab) (DK) | 1996-11-19 | — | — | US | disclosed |
| EP-0654026-A1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS. | LEO PHARM PROD LTD (DK) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003431-A1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1994-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200355-A1 | Method for Preparing Optically Pure (-)-Clausenamide Compound | ALDOA, COASY, HSD17B14 | TSHR 3408/4885EPHX1 267/4885CYP2C19 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.