Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746347 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL111475 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL8875725 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL14393160 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL14365934 | 1.00 | TSHR (1.00) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL2210689 | 0.88 | TSHR (0.79) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| Phenyl Propionic Acid SCHEMBL28865692 | 0.87 | TSHR (0.76) | TSHRALDH1A1 | |
| SCHEMBL14967814 | 0.87 | TSHR (0.77) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL6751902 | 0.85 | TSHR (0.74) | TSHREPHX1CYP2C19MEN1CYP1A2 | |
| SCHEMBL5316941 | 0.85 | TSHR (0.74) | TSHRCYP2C19MEN1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117904087-A | Halohydrin dehalogenase mutant and application thereof in preparation of chiral oxazolidinone | 中国科学院天津工业生物技术研究所 | 2024-04-19 | — | — | CN | claimed |
| CN-117904087-A | Halohydrin dehalogenase mutant and application thereof in preparation of chiral oxazolidinone | 中国科学院天津工业生物技术研究所 | 2024-04-19 | — | — | CN | disclosed |
| US-20220411716-A1 | Consumer Products with Improved Aesthetics | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2022-12-29 | — | — | US | disclosed |
| EP-3970690-A2 | CONSUMER PRODUCTS WITH IMPROVED AESTHETICS | International Flavors & Fragrances Inc. (US) | 2022-03-23 | — | — | EP | disclosed |
| US-7671238-B2 | Arylamino-arylpropanolamine derivatives and methods of their use | WYETH LLC (US) | 2010-03-02 | — | — | US | disclosed |
| US-7638512-B2 | Phenylaminopropanol derivatives and methods of their use | WYETH (US) | 2009-12-29 | — | — | US | disclosed |
| US-20090099164-A1 | Phenylaminopropanol Derivatives and Methods of Their Use | WYETH (US) | 2009-04-16 | — | — | US | disclosed |
| US-7517899-B2 | Phenylaminopropanol derivatives and methods of their use | WYETH (US) | 2009-04-14 | — | — | US | disclosed |
| US-20090093469-A1 | Phenylaminopropanol Derivatives and Methods of Their Use | WYETH (US) | 2009-04-09 | — | — | US | disclosed |
| US-20080255102-A1 | Phenylaminopropanol Derivatives and Methods of Their Use | WYETH (US) | 2008-10-16 | — | — | US | disclosed |
| US-20050222142-A1 | Phenylaminopropanol derivatives and methods of their use | WYETH (US) | 2005-10-06 | — | — | US | disclosed |
| US-20050222148-A1 | Phenylaminopropanol derivatives and methods of their use | WYETH (US) | 2005-10-06 | — | — | US | disclosed |
| US-5637739-A | ORGANOMETALLIC CATALYSTS FOR ENANTIOSELECTIVELY EPOXIDIZING PROCHIRAL OLEFINS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1997-06-10 | — | — | US | disclosed |
| EP-0654026-B1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1997-02-19 | — | — | EP | disclosed |
| EP-0643626-A4 | CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL. | RES CORP TECHNOLOGIES INC (US) | 1995-12-06 | — | — | EP | disclosed |
| EP-0643626-A1 | CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-03-22 | — | — | EP | disclosed |
| US-5234932-A | Bronchodilators, antiallergens, antiinflammatory agents | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1993-08-10 | — | — | US | disclosed |
| WO-1993003838-A1 | CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | disclosed |
| EP-0489831-A1 | Substituted quinolines, their preparation and their use as lipoxygenase inhibitors and/or leukotriene antagonists | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1992-06-17 | — | — | EP | disclosed |
| WO-1991003466-A1 | SUBSTITUTED QUINOLINES | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LØVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) | 1991-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099164-A1 | Phenylaminopropanol Derivatives and Methods of Their Use | PAH, PNMT, COMT | TSHR 3880/4885EPHX1 2367/4885CYP2C19 266/4885 |
| US-20050222148-A1 | Phenylaminopropanol derivatives and methods of their use | PAH, PNMT, COMT | TSHR 3880/4885EPHX1 2367/4885CYP2C19 266/4885 |
| US-20050222142-A1 | Phenylaminopropanol derivatives and methods of their use | PAH, PNMT, COMT | TSHR 3880/4885EPHX1 2367/4885CYP2C19 266/4885 |
| US-20080255102-A1 | Phenylaminopropanol Derivatives and Methods of Their Use | PAH, PNMT, COMT | TSHR 4150/4885EPHX1 2785/4885CYP2C19 317/4885 |
| US-20090093469-A1 | Phenylaminopropanol Derivatives and Methods of Their Use | PAH, PNMT, COMT | TSHR 3880/4885EPHX1 2367/4885CYP2C19 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.