SCHEMBL5317261

SCHEMBL5317261

Cc1c[nH]c(-c2n[nH]c3cccc(Cc4ccccc4)c23)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2D6 P10635 2/20 0.41
CYP2C9 P11712 2/20 0.41
CYP2C19 P33261 1/20 0.41
MAPK1 P28482 4/20 0.39
ADORA2A P29274 2/20 0.38
ADORA1 P30542 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
MAP2K4 P45985 2/20 0.36
MAPKAPK2 P49137 1/20 0.36
MAPK6 Q16659 1/20 0.36
GPR84 Q9NQS5 1/20 0.35
GAA P10253 1/20 0.34
HDAC6 Q9UBN7 2/20 0.34
NPC1 O15118 2/20 0.33
POLB P06746 2/20 0.33
NR1H2 P55055 1/20 0.33
NR1H3 Q13133 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8329288 0.74 PDE5A (0.40) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL5312041 0.74 MAPK1 (0.37) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL5314638 0.71 MAP2K4 (0.43) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL5313277 0.71 CYP3A4 (0.41) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL5315808 0.70 CYP1A2 (0.48) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL6854925 0.70 GAA (0.51) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL5314525 0.70 MAPK1 (0.34) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL5312171 0.70 CYP1A2 (0.44) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL7497118 0.69 SMN1; SMN2 (0.48) MAPK1MAP2K4MAPK6NPC1RAB9A
SCHEMBL7492078 0.69 MAP2K4 (0.59) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007065010-A2 ANTI-ANGIOGENESIS COMPOUNDS HIF BIO, INC. (US) 2007-06-07 WO disclosed
EP-0934311-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER AG (DE) 1999-08-11 EP disclosed
WO-1998016507-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO disclosed