SCHEMBL8329288

SCHEMBL8329288

Cc1ccc(-c2n[nH]c3cccc(Cc4ccccc4)c23)o1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE5A O76074 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
ALDH1A1 P00352 4/20 0.38
KDM4E B2RXH2 3/20 0.38
RAB9A P51151 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
MAPT P10636 2/20 0.38
HPGD P15428 2/20 0.38
NPC1 O15118 1/20 0.38
ADORA2A P29274 7/20 0.37
MAPK1 P28482 3/20 0.36
MAP2K4 P45985 2/20 0.36
MAPKAPK2 P49137 1/20 0.36
MAPK6 Q16659 1/20 0.36
PTGS1 P23219 1/20 0.36
PTGS2 P35354 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8470520 0.83 CYP1A2 (0.39) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL8470284 0.83 CYP2D6 (0.41) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL8472628 0.83 CYP3A4 (0.40) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL163795 0.83 HIF1A (0.44) PDE5ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL5971777 0.82 PDE5A (0.45) PDE5ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL5493286 0.82 KDM4E (0.41) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL8470062 0.81 CYP1A2 (0.36) PDE5ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8470320 0.80 MMP2 (0.43) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL5313810 0.75 MAP2K4 (0.37) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL5317261 0.74 CYP1A2 (0.41) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0932403-A1 USE OF CONDENSATED (HETARYL-SUBSTITUTED) 1-BENZAL-3-PYRAZOL DERIVATES FOR TREATING SPECIAL DISEASES OF THE CARDIOVASCULAR AND THE CENTRAL NERVOUS SYSTEMS BAYER AG (DE) 1999-08-04 EP claimed
WO-1998016223-A1 USE OF CONDENSATED (HETARYL-SUBSTITUTED) 1-BENZAL-3-PYRAZOL DERIVATES FOR TREATING SPECIAL DISEASES OF THE CARDIOVASCULAR AND THE CENTRAL NERVOUS SYSTEMS BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO claimed