SCHEMBL5314525

SCHEMBL5314525

COCc1oc(-c2n[nH]c3cccc(Cc4ccccc4)c23)nc1C

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.34
MAP2K4 P45985 1/20 0.34
MAPKAPK2 P49137 1/20 0.34
MAPK6 Q16659 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
PPARD Q03181 10/20 0.33
VDR P11473 8/20 0.33
LMNA P02545 1/20 0.31
ESR1 P03372 2/20 0.31
THRA P10827 2/20 0.31
THRB P10828 2/20 0.31
RXRA P19793 2/20 0.31
PPARG P37231 2/20 0.31
PPARA Q07869 2/20 0.31
ESR2 Q92731 2/20 0.31
FFAR1 O14842 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5314312 0.88 PPARD (0.34) MAPK1MAP2K4MAPKAPK2MAPK6PPARD
SCHEMBL5313810 0.87 MAP2K4 (0.37) MAPK1MAP2K4MAPKAPK2MAPK6CYP1A2
SCHEMBL5313829 0.87 ALDH1A1 (0.36) MAPK1MAP2K4MAPKAPK2MAPK6CYP1A2
SCHEMBL5971777 0.78 PDE5A (0.45) MAPK1MAP2K4MAPKAPK2MAPK6CYP1A2
SCHEMBL5312666 0.75 MAP4K1 (0.35) MAPK1MAP2K4MAPKAPK2MAPK6PPARD
SCHEMBL8329288 0.73 PDE5A (0.40) MAPK1MAP2K4MAPKAPK2MAPK6CYP1A2
SCHEMBL5430240 0.71 SMN1; SMN2 (0.42) LMNA
SCHEMBL5312041 0.70 MAPK1 (0.37) MAPK1MAP2K4MAPKAPK2MAPK6CYP1A2
SCHEMBL5493286 0.70 KDM4E (0.41) MAPK1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL5317261 0.70 CYP1A2 (0.41) MAPK1MAP2K4MAPKAPK2MAPK6CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007065010-A2 ANTI-ANGIOGENESIS COMPOUNDS HIF BIO, INC. (US) 2007-06-07 WO disclosed
EP-0934311-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER AG (DE) 1999-08-11 EP disclosed
WO-1998016507-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO disclosed