SCHEMBL5317356

SCHEMBL5317356

NC(=O)NC(=O)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.62
NPC1 O15118 3/20 0.62
CTDSP1 Q9GZU7 2/20 0.62
PTPN1 P18031 3/20 0.60
ALDH1A1 P00352 5/20 0.57
KMT2A Q03164 4/20 0.57
MEN1 O00255 3/20 0.57
DEGS1 O15121 1/20 0.56
PDCD1 Q15116 1/20 0.56
CD274 Q9NZQ7 1/20 0.56
SMN1; SMN2 Q16637 3/20 0.54
POLB P06746 2/20 0.54
STAT3 P40763 1/20 0.54
NPSR1 Q6W5P4 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
LMNA P02545 1/20 0.54
GAA P10253 1/20 0.54
ALOX12 P18054 1/20 0.54
RXFP1 Q9HBX9 1/20 0.54
HPGDS O60760 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL28074647 0.87 ALDH1A1 (0.69) RAB9ANPC1PTPN1ALDH1A1KMT2A
SCHEMBL40525 0.87 ALDH1A1 (0.69) RAB9ANPC1PTPN1ALDH1A1KMT2A
SCHEMBL28166896 0.87 ALDH1A1 (0.69) RAB9ANPC1PTPN1ALDH1A1KMT2A
Hydrogen Sulfide SCHEMBL27878891 0.85 ALDH1A1 (0.67) RAB9ANPC1PTPN1ALDH1A1KMT2A
Hydrochloric Acid SCHEMBL30829222 0.85 ALDH1A1 (0.67) RAB9ANPC1PTPN1ALDH1A1KMT2A
Urea SCHEMBL28373374 0.85 ALDH1A1 (0.67) RAB9ANPC1PTPN1ALDH1A1KMT2A
Fluoride SCHEMBL27889058 0.85 ALDH1A1 (0.67) RAB9ANPC1PTPN1ALDH1A1KMT2A
Methane SCHEMBL28614489 0.85 ALDH1A1 (0.67) RAB9ANPC1PTPN1ALDH1A1KMT2A
SCHEMBL5441715 0.85 RAB9A (0.58) RAB9ANPC1CTDSP1PTPN1ALDH1A1
Hydrochloric Acid SCHEMBL8701937 0.83 RAB9A (0.56) RAB9ANPC1CTDSP1PTPN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007077457-A9 TREATMENT OF EQUINE LAMINITIS WITH 5-HT1B/ 1D ANTAGONISTS ROYAL VETERINARY COLLEGE (GB) 2007-10-18 WO disclosed
EP-0726889-A1 PROCESS FOR PREPARING SUBSTITUTED AROMATIC AMINES MONSANTO COMPANY (US) 1996-08-21 EP disclosed
WO-1995012569-A1 PROCESS FOR PREPARING SUBSTITUTED AROMATIC AMINES MONSANTO COMPANY (US) 1995-05-11 WO disclosed