SCHEMBL5317376

SCHEMBL5317376

CCCCOC(=O)N1C2CCC1CC(=O)C2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.42
LMNA P02545 2/20 0.42
POLB P06746 1/20 0.42
ALDH1A1 P00352 2/20 0.39
BCHE P06276 1/20 0.38
ATM Q13315 1/20 0.37
GBA2 Q9HCG7 1/20 0.36
TSHR P16473 3/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
GRM5 P41594 1/20 0.35
HPGD P15428 1/20 0.35
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
ESR1 P03372 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29650103 1.00 SMN1; SMN2 (0.42) SMN1; SMN2LMNAPOLBALDH1A1BCHE
SCHEMBL29461904 0.94 MAPK1 (0.42) SMN1; SMN2LMNAPOLBALDH1A1BCHE
SCHEMBL20942090 0.90 KDM4E (0.37) ALDH1A1MEN1KMT2AGRM5CHRM2
SCHEMBL22323609 0.87 SMN1; SMN2 (0.46) SMN1; SMN2LMNAPOLBALDH1A1BCHE
SCHEMBL29542888 0.87 SMN1; SMN2 (0.46) SMN1; SMN2LMNAPOLBALDH1A1BCHE
SCHEMBL8259755 0.86 SMN1; SMN2 (0.41) SMN1; SMN2LMNAPOLBALDH1A1BCHE
SCHEMBL1016674 0.85 CHRM1 (0.42) L3MBTL1GRM5CHRM2CHRM1CHRM3
SCHEMBL15618675 0.85 CHRM1 (0.42) L3MBTL1GRM5CHRM2CHRM1CHRM3
SCHEMBL31612922 0.83 LMNA (0.43) SMN1; SMN2LMNAPOLBALDH1A1BCHE
SCHEMBL12199159 0.82 LMNA (0.45) SMN1; SMN2LMNAPOLBALDH1A1BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4463457-A1 PYRROLO[1,2-/b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS Suven Life Sciences Limited (IN) 2024-11-20 EP disclosed
EP-2976340-A1 CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2016-01-27 EP disclosed
EP-2877471-A1 SPIRO - FUSED PIPERIDINE DERIVATIVES FOR USE AS INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL Merck Sharp & Dohme Corp. (US) 2015-06-03 EP disclosed
WO-2014146490-A1 CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2014-09-25 WO disclosed
WO-2014018764-A1 SPIRO - FUSED PIPERIDINE DERIVATIVES FOR USE AS INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL MERCK SHARP & DOHME CORP. (US) 2014-01-30 WO disclosed
WO-2007079239-A2 BICYCLIC NITROGEN COMPOUNDS AS MODULATORS OF GHRELIN RECEPTOR AND USES THEREOF ACADIA PHARMACEUTICALS INC. (US) 2007-07-12 WO disclosed