SCHEMBL1016674

SCHEMBL1016674

CCOC(=O)N1C2CCC1CC(=O)C2

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 15/20 0.42
CHRM4 P08173 1/20 0.42
CHRM5 P08912 1/20 0.42
GRM5 P41594 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
CHRM2 P08172 1/20 0.39
CHRM3 P20309 1/20 0.39
GAA P10253 1/20 0.39
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15618675 1.00 CHRM1 (0.42) CHRM1CHRM4CHRM5GRM5L3MBTL1
SCHEMBL3745563 0.93 MAPK1 (0.48) CHRM1CHRM4CHRM5GRM5L3MBTL1
SCHEMBL20942090 0.88 KDM4E (0.37) CHRM1CHRM4CHRM5GRM5CHRM2
SCHEMBL29650103 0.85 SMN1; SMN2 (0.42) CHRM1GRM5L3MBTL1CHRM2CHRM3
SCHEMBL5317376 0.85 SMN1; SMN2 (0.42) CHRM1GRM5L3MBTL1CHRM2CHRM3
SCHEMBL21597914 0.84 CHRM1 (0.40) CHRM1CHRM4CHRM5GRM5L3MBTL1
SCHEMBL12873753 0.81 GRM5 (0.42) CHRM1GRM5CHRM2CHRM3MAPK1
SCHEMBL11731279 0.81 GRM5 (0.42) CHRM1GRM5CHRM2CHRM3MAPK1
SCHEMBL2148232 0.81 CHRM1 (0.41) CHRM1CHRM4CHRM5GRM5CHRM2
SCHEMBL20942086 0.81 SLC6A3 (0.33) CHRM1CHRM2CHRM3MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 230 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4714446-A2 PHARMACEUTICAL COMPOUNDS Nxera Pharma UK Limited (GB) 2026-03-25 EP disclosed
EP-4665718-A1 SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF Apogee Pharmaceuticals, Inc. (CA) 2025-12-24 EP disclosed
EP-3638658-B1 PHARMACEUTICAL COMPOUNDS NXERA PHARMA UK LTD (GB) 2025-10-08 EP disclosed
US-12378231-B2 Small molecules as monoacylglycerol lipase (MAGL) inhibitors, compositions and use thereof APOGEE PHARMACEUTICALS, INC. (CA) 2025-08-05 US disclosed
US-12202843-B2 Muscarinic receptor agonists NXERA PHARMA UK LIMITED (GB) 2025-01-21 US disclosed
US-20240294514-A1 SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF APOGEE PHARMACEUTICALS, INC. (CA) 2024-09-05 US disclosed
WO-2024168426-A1 SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF APOGEE PHARMACEUTICALS, INC. (CA) 2024-08-22 WO disclosed
EP-4413985-A2 PHARMACEUTICAL COMPOUNDS Nxera Pharma UK Limited (GB) 2024-08-14 EP disclosed
US-20240165097-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR DEMENTIA NXERA PHARMA UK LIMITED (GB) 2024-05-23 US disclosed
US-11945801-B2 Bicyclic aza compounds as muscarinic M1 and/or M4 receptor agonists HEPTARES THERAPEUTICS LIMITED (GB) 2024-04-02 US disclosed
US-5663182-A ADMINISTERING AN AZABICYCLIC RING SUBSTITUTED THIADIAZOLE OR OXADIAZOLE TO A MAMMAL BYMASTER FRANKLIN PORTER (US) 1997-09-02 US disclosed
US-5641791-A USEFUL AS STIMULANTS OF COGNITIVE FUNCTION OF FOREBRAIN AND HIPPOCAMPUS OF MAMMALS AND IN THE TREATMENT OF ALZHIEMER'S DISEASE, SEVERE PAIN AND GLAUCOMA NOVO NORDISK A.S (DK) 1997-06-24 US disclosed
US-5612351-A AZABICYCLIC DERIVATIVES OF 1,2,3-OXA(OR THIA)DIAZOLE NOVO NORDISK A/S (DK) 1997-03-18 US disclosed
US-5578602-A FOR STIMULATING COGNITIVE FUNCTIONS OF THE BRAIN, TREATING ALZHEIMER*S DISEASE, GLAUCOMA OR PAIN NOVO NORDISK A/S (DK) 1996-11-26 US disclosed
US-5574043-A ALZHEIMERS, GLAUCOMA, ANALGESIC NOVO NORDISK A/S (DK) 1996-11-12 US disclosed
US-5527813-A THERAPEUTICALLY ACTIVE AZABICYCLIC COMPOUNDS USEFUL AS STIMULANTS OF THE COGNITIVE FUNCTION OF THE FOREBRAIN AND IN THE TREATMENT OF ALZHEIMER'S DISEASE NOVO NORDISK A/S (DK) 1996-06-18 US disclosed
US-5260314-A Cognition activators, glaucoma analgesic NOVO NORDISK A/S (DK) 1993-11-09 US disclosed
EP-0544779-A1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1993-06-09 EP disclosed
WO-1992003433-A1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1992-03-05 WO disclosed
US-4277472-A 3,6-Disubstituted-5,7-(lower alkano)-5,6,7,8-tetrahydropyrido(4,3-C)pyridazines; their intermediates, preparation, antihypertensive use and compositions BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1981-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12202843-B2 Muscarinic receptor agonists CHRM1, CHRM2, CHRM3 CHRM1 1/4885CHRM4 5/4885CHRM5 4/4885
US-11945801-B2 Bicyclic aza compounds as muscarinic M1 and/or M4 receptor agonists CHRM1, CHRM2, CHRM4 CHRM1 1/4885CHRM4 3/4885CHRM5 4/4885
US-12378231-B2 Small molecules as monoacylglycerol lipase (MAGL) inhibitors, compositions and use thereof MGLL, PNLIP, LPL CHRM1 3653/4885CHRM4 4014/4885CHRM5 3223/4885
US-20240165097-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR DEMENTIA CHRM1, CHRM2, CHRM4 CHRM1 1/4885CHRM4 3/4885CHRM5 4/4885
US-20240294514-A1 SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF MGLL, PNLIP, LPL CHRM1 3653/4885CHRM4 4014/4885CHRM5 3223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.