Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4863766 | 0.77 | MAPK1 (0.46) | NOTUMMAPK1 | |
| SCHEMBL5822563 | 0.77 | BRD4 (0.42) | NOTUMHTTALDH1A1MAPTGAA | |
| SCHEMBL30125059 | 0.77 | BRD4 (0.42) | NOTUMHTTALDH1A1MAPTGAA | |
| SCHEMBL20219731 | 0.73 | BRD4 (0.42) | NOTUMKMT2AKDM4ETSHRLMNA | |
| SCHEMBL31475696 | 0.72 | CA12 (0.47) | HTTALDH1A1MAPTGAAMEN1 | |
| SCHEMBL5320723 | 0.71 | MAPK8 (0.40) | HTTALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5320718 | 0.71 | MAPK8 (0.40) | HTTALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5317820 | 0.70 | NPC1 (0.37) | ALDH1A1GAAMEN1KMT2AMAPK1 | |
| SCHEMBL28165435 | 0.67 | MAPT (0.41) | NOTUMALDH1A1MAPTGAAMEN1 | |
| SCHEMBL7003872 | 0.66 | NOTUM (0.73) | NOTUMHTTALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537117-B1 | BENZOTRIAZABICYCLIC DERIVATIVES AND USE THEREOF AS BETA-LACTAMASE INHIBITORS AND ANTI-BACTERIAL AGENTS | AVENTIS PHARMA SA (FR) | 2007-01-17 | — | — | EP | disclosed |