Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.73 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.53 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3030097 | 0.89 | NOTUM (0.59) | NOTUMKCNN4KCNA3LMNARAB9A | |
| SCHEMBL30003296 | 0.85 | NOTUM (1.00) | NOTUMKCNN4KCNA3LMNARAB9A | |
| SCHEMBL1048074 | 0.85 | NOTUM (1.00) | NOTUMKCNN4KCNA3LMNARAB9A | |
| SCHEMBL68111 | 0.84 | KCNN4 (0.68) | NOTUMKCNN4KCNA3LMNARAB9A | |
| SCHEMBL28021992 | 0.81 | LMNA (0.68) | NOTUMLMNARAB9AHTTMEN1 | |
| SCHEMBL29634379 | 0.79 | SMN1; SMN2 (0.51) | NOTUMKCNN4KCNA3LMNARAB9A | |
| SCHEMBL5711999 | 0.79 | NOTUM (0.70) | NOTUMKCNN4KCNA3LMNARAB9A | |
| SCHEMBL3037573 | 0.78 | KCNN4 (0.78) | NOTUMKCNN4KCNA3LMNARAB9A | |
| SCHEMBL30667212 | 0.75 | NOTUM (0.64) | NOTUMKCNN4KCNA3LMNARAB9A | |
| SCHEMBL7004709 | 0.75 | NOTUM (0.64) | NOTUMKCNN4KCNA3LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-06-05 | — | — | US | disclosed |
| EP-1288216-A1 | TRICYCLIC QUINAZOLINEDIONES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | PARP1, PARP11, PARP2 | NOTUM 4410/4885KCNN4 1557/4885KCNA3 3007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.