Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.63 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524328 | 0.88 | NR4A2 (0.50) | NR4A2NUDT1MAPK13MAPK12MAPK11 | |
| SCHEMBL22925728 | 0.84 | KDM4E (0.48) | NR4A2NUDT1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL342242 | 0.79 | MAPK13 (0.58) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4523610 | 0.79 | RAB9A (0.45) | NR4A2MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL22925906 | 0.78 | KIF11 (0.46) | NR4A2NOTUMALDH1A1NPC1 | |
| SCHEMBL869242 | 0.78 | GAA (0.51) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL330227 | 0.78 | NR4A2 (1.00) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL272772 | 0.76 | NPC1 (0.50) | MAPK13MAPK12MAPK11MAPK14ELANE | |
| SCHEMBL4518811 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL482742 | 0.74 | MAPK13 (0.45) | NR4A2MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2023061294-A1 | NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 再鼎医药(上海)有限公司 | 2023-04-20 | — | — | WO | disclosed |