Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.81 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.58 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.50 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318309 | 0.90 | HDAC6 (0.76) | HDAC6EHMT2EHMT1CYP3A4HDAC1 | |
| SCHEMBL19058676 | 0.90 | HDAC6 (1.00) | HDAC6HDAC1 | |
| SCHEMBL4980587 | 0.81 | HDAC6 (0.64) | HDAC6CYP3A4GSK3BMAOAMAOB | |
| SCHEMBL6530892 | 0.80 | L3MBTL1 (0.58) | HDAC6EHMT2EHMT1CSNK2A1CSNK2A2 | |
| SCHEMBL5317461 | 0.80 | HDAC6 (0.62) | HDAC6TP53MAPT | |
| SCHEMBL4980845 | 0.79 | HDAC6 (0.61) | HDAC6CYP3A4GSK3BMAOAMAOB | |
| SCHEMBL5317666 | 0.79 | HDAC6 (0.52) | HDAC6EHMT2EHMT1HSD17B10KDM4E | |
| SCHEMBL22382419 | 0.78 | EHMT2 (0.53) | HDAC6EHMT2EHMT1HDAC1HSD17B10 | |
| SCHEMBL5320017 | 0.77 | HDAC6 (0.50) | HDAC6EHMT2EHMT1HSD17B10KDM4E | |
| SCHEMBL6320502 | 0.76 | HDAC6 (0.53) | HDAC6EHMT2EHMT1HDAC1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |