Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | ITK | Q08881 | 12/20 | 0.54 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320783 | 0.83 | ITK (0.47) | ITKMRGPRX2 | |
| SCHEMBL5316556 | 0.81 | HDAC6 (0.63) | HDAC6ITKMRGPRX2LMNAADORA2A | |
| SCHEMBL5318327 | 0.80 | HDAC6 (0.81) | HDAC6TP53MAPT | |
| SCHEMBL5315622 | 0.78 | TLR9 (0.46) | ITKMRGPRX2ADORA2AADORA1 | |
| SCHEMBL5315400 | 0.77 | FLT3 (0.48) | ITK | |
| SCHEMBL19058676 | 0.77 | HDAC6 (1.00) | HDAC6 | |
| SCHEMBL5318309 | 0.77 | HDAC6 (0.76) | HDAC6TP53MAPT | |
| SCHEMBL5320022 | 0.76 | ADORA2A (0.49) | HDAC6ITKMRGPRX2ADORA2AADORA1 | |
| SCHEMBL5319144 | 0.75 | LMNA (0.60) | ITKMRGPRX2LMNAADORA2AADORA1 | |
| SCHEMBL5316718 | 0.71 | LMNA (0.49) | ITKMRGPRX2LMNAADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |