Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.48 |
| ▸ | PTPRC | P08575 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320486 | 0.82 | PTPN1 (0.36) | PTPN1PTPN2PTPRCPTGS2PPARG | |
| SCHEMBL5322648 | 0.81 | PTPN1 (0.51) | PTPN1PTPN2PTPRCALDH1A1KMT2A | |
| SCHEMBL14090377 | 0.80 | PTPN1 (0.46) | PTPN1PTPN2PTPRC | |
| SCHEMBL4897308 | 0.78 | PTPN1 (0.45) | PTPN1PTPN2PTPRCL3MBTL1 | |
| SCHEMBL5343124 | 0.76 | PTPN1 (0.47) | PTPN1PTPN2PTPRC | |
| SCHEMBL5344606 | 0.75 | HDAC1 (0.53) | PTPN1PTPN2PTPRCALDH1A1PPARG | |
| SCHEMBL4899977 | 0.75 | PTPN1 (0.43) | PTPN1PTPN2PTPRC | |
| SCHEMBL4901303 | 0.75 | PTPN1 (0.46) | PTPN1PTPN2PTPRCL3MBTL1ALDH1A1 | |
| SCHEMBL4901508 | 0.75 | PTPN1 (0.40) | PTPN1PTPN2PTPRCL3MBTL1PTGS2 | |
| SCHEMBL4891791 | 0.74 | PTPN1 (0.45) | PTPN1PTPN2PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081755-A2 | INDOLE-BENZIMIDAZOLE AND INDAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | METABASIS THERAPEUTICS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007081755-A2 | INDOLE-BENZIMIDAZOLE AND INDAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | METABASIS THERAPEUTICS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |