Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 20/20 | 0.45 |
| ▸ | MMP14 | P50281 | 10/20 | 0.45 |
| ▸ | MMP12 | P39900 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3338479 | 1.00 | MMP13 (0.45) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL587210 | 0.88 | MMP13 (0.41) | MMP13MMP14MMP12 | |
| SCHEMBL5492391 | 0.86 | MMP13 (0.44) | MMP13MMP14MMP12 | |
| SCHEMBL587505 | 0.86 | MMP13 (0.44) | MMP13MMP14MMP12 | |
| SCHEMBL587427 | 0.84 | MMP13 (0.43) | MMP13MMP14MMP12 | |
| SCHEMBL3109399 | 0.82 | MMP13 (0.42) | MMP13MMP14MMP12 | |
| SCHEMBL3339306 | 0.82 | MMP13 (0.54) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL3337202 | 0.82 | CYP11B1 (0.50) | MMP13MMP14 | |
| SCHEMBL3338616 | 0.80 | MMP13 (0.45) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL3337043 | 0.79 | MMP13 (0.44) | MMP13MMP14MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831196-A1 | NOVEL HYDANTOIN DERIVATIVES AS METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006065216-A1 | NOVEL HYDANTOIN DERIVATIVES AS METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |