Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 5/20 | 0.41 |
| ▸ | FLT4 | P35916 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP7 | P09237 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142857 | 0.71 | ALDH1A1 (0.42) | MEN1KMT2ALMNAL3MBTL1FLT1 | |
| SCHEMBL5585010 | 0.71 | ALDH1A1 (0.42) | MEN1KMT2ALMNAL3MBTL1FLT1 | |
| SCHEMBL5585266 | 0.69 | CNR1 (0.41) | MEN1KMT2ALMNAL3MBTL1FLT1 | |
| SCHEMBL5144983 | 0.69 | CNR1 (0.41) | MEN1KMT2ALMNAL3MBTL1FLT1 | |
| SCHEMBL5585265 | 0.69 | CNR1 (0.41) | MEN1KMT2ALMNAL3MBTL1FLT1 | |
| SCHEMBL15617658 | 0.68 | ALDH1A1 (0.49) | MEN1KMT2AL3MBTL1FLT1FLT4 | |
| SCHEMBL5147325 | 0.68 | CNR1 (0.73) | CNR1CNR2 | |
| SCHEMBL29244487 | 0.67 | FLT1 (0.54) | FLT1FLT4KDRMMP2MMP1 | |
| SCHEMBL3192988 | 0.67 | CYP2D6 (0.53) | MEN1KMT2ALMNACNR1CNR2 | |
| SCHEMBL1287451 | 0.67 | CYP2D6 (0.53) | MEN1KMT2ALMNACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663113-A4 | SUBSTITUTED SULFONAMIDES | MERCK & CO INC (US) | 2007-06-13 | — | — | EP | disclosed |
| EP-1663113-A2 | SUBSTITUTED SULFONAMIDES | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005027837-A2 | SUBSTITUTED SULFONAMIDES | MERCK & CO., INC. (US) | 2005-03-31 | — | — | WO | disclosed |