Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tramadol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 13/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 13/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 6/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 4/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R,R)-Tramadol SCHEMBL14579837 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL7464 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL12831358 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL6543836 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL1593740 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL3265792 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL5318670 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL11984200 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL730723 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL57495 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 587 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017199014-A1 | TREATMENT OF OPIOID TOLERANCE | UNIVERSITY OF DUNDEE (GB) | 2017-11-23 | — | — | WO | claimed |
| US-20160039742-A1 | EXTRACTION OF TRAMADOL FROM NAUCLEA LATIFOLIA SMITH | UNIVERSITE JOSEPH FOURIER - GRENOBLE 1 (FR) | 2016-02-11 | — | — | US | claimed |
| EP-1363872-B1 | METHOD FOR ISOLATING AND PURIFYING (1RS,2RS)-2- (DIMETHYLAMINO)METHYL -1-(3-METHOXYPHENYL)-CYCLOHEXANOL | GRUENENTHAL GMBH (DE) | 2008-08-20 | — | — | EP | claimed |
| EP-1527043-B1 | METHOD FOR THE PRODUCTION OF 2- (DIMETHYLAMINO)METHYL|-1-(3-METHOXYPHENYL)CYCLOHEXANOL | GRUENENTHAL GMBH (DE) | 2006-10-04 | — | — | EP | claimed |
| WO-2006053012-A2 | NOVEL PHARMACEUTICAL COMPOSITIONS FOR TREATING ACQUIRED CHRONIC PAIN AND ASSOCIATED DYSPHORIA | TRINITY LABORATORIES, INC. (US) | 2006-05-18 | — | — | WO | claimed |
| US-7030276-B2 | Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol | GRUENENTHAL GMBH (DE) | 2006-04-18 | — | — | US | claimed |
| US-20050215821-A1 | Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol | GRUENENTHAL GMBH (DE) | 2005-09-29 | — | — | US | claimed |
| US-6909017-B2 | Method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol | GRUNENTHAL GMBH (DE) | 2005-06-21 | — | — | US | claimed |
| EP-1527043-A1 | METHOD FOR THE PRODUCTION OF 2- (DIMETHYLAMINO)METHYL]-1-(3-METHOXYPHENYL)CYCLOHEXANOL | Grünenthal GmbH (DE) | 2005-05-04 | — | — | EP | claimed |
| US-20040225154-A1 | Method for isolating and purifying (1RS,2RS)-2-[ (dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol | GRUNENTHAL GMBH (DE) | 2004-11-11 | — | — | US | claimed |
| EP-1135357-A1 | PROCESS FOR THE RESOLUTION OF TRAMADOL | Darwin Discovery Limited (GB) | 2001-09-26 | — | — | EP | claimed |
| EP-0778262-B1 | Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts | CHEMAGIS LTD (IL) | 2001-01-24 | — | — | EP | claimed |
| US-6169205-B1 | Process for the purification of (RR,SS)-2-(dimethylamino) methyl-1-(3-methoxyphenyl)-cyclohexanol from (RS,SR)-2-(dimethylamino)methyl-1-(3-methoxyphenyl) cyclohexanol | DIPHARMA S.P.A. (IT) | 2001-01-02 | — | — | US | claimed |
| WO-2000032554-A1 | PROCESS FOR THE RESOLUTION OF TRAMADOL | DARWIN DISCOVERY LIMITED (GB) | 2000-06-08 | — | — | WO | claimed |
| EP-0940385-A1 | Process for the separation of the (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanol isomer from the (RS,SR) isomer by selective precipitation | Dinamite Dipharma S.p.A. (IT) | 1999-09-08 | — | — | EP | claimed |
| US-5877351-A | REACTION WITH HYDROGEN BROMIDE | WYCKOFF CHEMICAL COMPANY, INC. (US) | 1999-03-02 | — | — | US | claimed |
| US-5874620-A | ADDING AN ELECTROPHIOLIC REAGENT TO A MIXTURE OF (RR,SS)-TRAMADOL HYDROCHLORIDE AND ITS (RS,SR) GEOMETRICAL ISOMER; REGIOSELECTIVE REACTION WITH THE HYDROXYL GROUP OF THE RS,SR-TRAMADOL LEAVING PURE (RR,SS) ISOMER | CHEMAGIS, LTD. (IL) | 1999-02-23 | — | — | US | claimed |
| EP-0831082-A1 | Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride | Chemagis Ltd. (IL) | 1998-03-25 | — | — | EP | claimed |
| US-5672755-A | Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts | CHEMAGIS LTD. (IL) | 1997-09-30 | — | — | US | claimed |
| EP-0778262-A2 | Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts | Chemagis Ltd. (IL) | 1997-06-11 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040225154-A1 | Method for isolating and purifying (1RS,2RS)-2-[ (dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol | MRPS27, MAN1B1, MCRS1 | OPRM1 470/4885SLC6A2 2496/4885SLC6A4 2629/4885 |
| US-20160039742-A1 | EXTRACTION OF TRAMADOL FROM NAUCLEA LATIFOLIA SMITH | OPRK1, OPRD1, OPRM1 | OPRM1 3/4885SLC6A2 15/4885SLC6A4 405/4885 |
| US-20050215821-A1 | Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol | DGKA, DEGS1, GRIK2 | OPRM1 937/4885SLC6A2 3686/4885SLC6A4 3926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.