Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 19/20 | 0.75 |
| ▸ | HDAC4 | P56524 | 19/20 | 0.75 |
| ▸ | HDAC1 | Q13547 | 19/20 | 0.75 |
| ▸ | HDAC7 | Q8WUI4 | 19/20 | 0.75 |
| ▸ | HDAC2 | Q92769 | 19/20 | 0.75 |
| ▸ | HDAC10 | Q969S8 | 19/20 | 0.75 |
| ▸ | HDAC11 | Q96DB2 | 19/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 19/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.75 |
| ▸ | HDAC9 | Q9UKV0 | 19/20 | 0.75 |
| ▸ | HDAC5 | Q9UQL6 | 19/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318461 | 0.87 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4814884 | 0.86 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5322258 | 0.86 | LMNA (0.77) | HDAC1LMNASMN1; SMN2 | |
| SCHEMBL5662797 | 0.85 | HDAC3 (0.79) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5318770 | 0.85 | SMN1; SMN2 (0.68) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5337422 | 0.84 | HDAC3 (0.81) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5660878 | 0.84 | HDAC3 (0.72) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5316716 | 0.83 | HDAC3 (0.80) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5315214 | 0.83 | HDAC3 (0.80) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5318728 | 0.83 | HDAC3 (0.80) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067993-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007067993-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |