Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975093 | 0.91 | MAPT (0.47) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL31118853 | 0.84 | MAPT (0.56) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL189811 | 0.84 | MAPT (0.56) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL4976688 | 0.84 | CYP19A1 (0.48) | MAPK1ALDH1A1PTGS2TDP1CYP19A1 | |
| Butane SCHEMBL9017614 | 0.79 | CYP19A1 (0.44) | MAPK1ALDH1A1PTGS2TDP1CYP19A1 | |
| SCHEMBL5159592 | 0.79 | MAPT (0.39) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL11273785 | 0.79 | CYP19A1 (0.50) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL3508166 | 0.78 | LOXL2 (0.48) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL29008515 | 0.75 | TAAR1 (0.49) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL30386000 | 0.75 | TAAR1 (0.49) | MAPTMEN1KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797067-A1 | NEW HETEROCYCLIC AMIDES | AstraZeneca AB (SE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006033620-A1 | NEW HETEROCYCLIC AMIDES | ASTRAZENECA AB (SE) | 2006-03-30 | — | — | WO | disclosed |