Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435102 | 0.92 | POLB (0.57) | POLBMCL1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL14434468 | 0.91 | POLB (0.56) | POLBLMNAMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5321343 | 0.90 | POLB (0.52) | POLBMCL1BCL2A1LMNAMAPK1 | |
| SCHEMBL14434470 | 0.90 | POLB (0.55) | POLBSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14434878 | 0.90 | POLB (0.57) | POLBLMNAMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL5375793 | 0.88 | POLB (0.53) | POLBSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5435703 | 0.88 | ALDH1A1 (0.53) | POLBMCL1BCL2A1LMNASMN1; SMN2 | |
| SCHEMBL14434885 | 0.87 | POLB (0.52) | POLBLMNAMAPK1MEN1KMT2A | |
| SCHEMBL14434880 | 0.86 | POLB (0.53) | POLBLMNAMEN1KMT2A | |
| SCHEMBL14434465 | 0.86 | POLB (0.53) | POLBLMNAMAPK1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007091140-A1 | SUBSTITUTED PHENYLSULFAMOYL COMPOUNDS AS PPAR AGONISTS | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007091140-A1 | SUBSTITUTED PHENYLSULFAMOYL COMPOUNDS AS PPAR AGONISTS | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |