Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18806165 | 0.74 | — | — | |
| SCHEMBL2302148 | 0.71 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL24740824 | 0.70 | POLB (0.31) | — | |
| SCHEMBL13751286 | 0.68 | DPP4 (0.38) | — | |
| SCHEMBL13740583 | 0.68 | DPP4 (0.38) | — | |
| SCHEMBL7528129 | 0.68 | MMP1 (0.36) | — | |
| SCHEMBL7528133 | 0.68 | MMP1 (0.36) | — | |
| SCHEMBL7528125 | 0.68 | MMP1 (0.36) | — | |
| SCHEMBL3533072 | 0.67 | MMP1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL3530197 | 0.67 | MMP1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084314-A2 | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-07-26 | — | — | WO | claimed |