Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | KIF20A | O95235 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13451628 | 0.80 | MTNR1A (0.42) | HTR2AHTR2BHTR2CHTR1AHTR7 | |
| SCHEMBL2072816 | 0.78 | MTNR1A (0.43) | HTR2AHTR2BHTR2CHTR1AHTR7 | |
| SCHEMBL1714319 | 0.76 | MTNR1A (0.44) | HTR2AHTR2BHTR2CMTNR1AMTNR1B | |
| SCHEMBL1714318 | 0.76 | MTNR1A (0.44) | HTR2AHTR2BHTR2CMTNR1AMTNR1B | |
| SCHEMBL2072930 | 0.74 | MTNR1A (0.43) | HTR2AHTR2BHTR1AHTR7HTR5A | |
| SCHEMBL5230871 | 0.73 | HTR2A (0.45) | HTR2AHTR2BHTR2CHTR1AHTR7 | |
| SCHEMBL12460836 | 0.73 | MTNR1A (0.45) | HTR2AHTR2BHTR2CMTNR1AMTNR1B | |
| SCHEMBL25990382 | 0.71 | HTR2A (0.53) | HTR2AHTR2BHTR2CHTR1AHTR7 | |
| SCHEMBL2074376 | 0.71 | SLC6A4 (0.53) | HTR2AHTR2BHTR1AHTR7HTR5A | |
| SCHEMBL2070997 | 0.71 | SLC6A4 (0.53) | HTR2AHTR2BHTR1AHTR7HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756054-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005118539-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2005-12-15 | — | — | WO | disclosed |