Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | HAT1 | O14929 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1714319 | 0.91 | MTNR1A (0.44) | MTNR1AMTNR1BKMT2AMEN1HAT1 | |
| SCHEMBL1714318 | 0.91 | MTNR1A (0.44) | MTNR1AMTNR1BKMT2AMEN1HAT1 | |
| SCHEMBL1713519 | 0.90 | MTNR1A (0.42) | MTNR1AMTNR1BKMT2AMEN1HAT1 | |
| SCHEMBL1713521 | 0.90 | MTNR1A (0.42) | MTNR1AMTNR1BKMT2AMEN1HAT1 | |
| SCHEMBL12461079 | 0.85 | MTNR1A (0.41) | MTNR1AMTNR1BKMT2AMEN1HAT1 | |
| SCHEMBL1713524 | 0.82 | MTNR1A (0.39) | MTNR1AMTNR1BKMT2AMEN1HAT1 | |
| SCHEMBL1714010 | 0.77 | MTNR1A (0.46) | MTNR1AMTNR1BHAT1EP300HTR2A | |
| SCHEMBL1714014 | 0.77 | MTNR1A (0.46) | MTNR1AMTNR1BHAT1EP300HTR2A | |
| SCHEMBL3224665 | 0.73 | JAK2 (0.39) | MAPTTDP1 | |
| SCHEMBL27479109 | 0.73 | HTR2A (0.51) | MTNR1AMTNR1BKMT2AMEN1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957454-B1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |
| US-7598399-B2 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC (US) | 2009-10-06 | — | — | US | disclosed |
| US-7598399-B2 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
| WO-2007062994-A1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | TPH1, TPH2, HTR1A | MTNR1A 25/4885MTNR1B 38/4885KMT2A 445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.