Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2022865 | 0.87 | HRH3 (0.45) | — | |
| SCHEMBL2019146 | 0.87 | SIGMAR1 (0.43) | — | |
| SCHEMBL2024648 | 0.84 | LIPG (0.37) | LIPGPARP1CYP2C9PPARGFAAH | |
| SCHEMBL8272736 | 0.80 | NPC1 (0.46) | FAAH | |
| SCHEMBL8272733 | 0.80 | MCHR1 (0.41) | PARP1CYP2C9PPARGFAAHMGLL | |
| SCHEMBL8272058 | 0.80 | HRH3 (0.48) | FAAHPREP | |
| SCHEMBL2022587 | 0.79 | MEN1 (0.41) | PARP1CYP2C9PPARGFAAHMGLL | |
| SCHEMBL2028181 | 0.77 | SIGMAR1 (0.41) | GRM2 | |
| SCHEMBL2022411 | 0.76 | PARP1 (0.52) | PARP1EGLN1PREP | |
| SCHEMBL12441927 | 0.75 | PARP1 (0.40) | LIPGPARP1PARP2DAODRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |