Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 6/20 | 0.56 |
| ▸ | FLT4 | P35916 | 6/20 | 0.56 |
| ▸ | KDR | P35968 | 6/20 | 0.56 |
| ▸ | IMPDH2 | P12268 | 7/20 | 0.43 |
| ▸ | VCP | P55072 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5344443 | 0.87 | KDR (0.59) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5334372 | 0.85 | KDR (0.59) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5336694 | 0.81 | FLT1 (0.52) | FLT1FLT4KDRIMPDH2CLK1 | |
| SCHEMBL5334189 | 0.81 | FLT1 (0.52) | FLT1FLT4KDRIMPDH2CLK1 | |
| SCHEMBL5336708 | 0.80 | VCP (0.57) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5316862 | 0.80 | KDR (0.62) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5345073 | 0.80 | RET (0.53) | FLT1FLT4KDRCLK1DYRK1A | |
| SCHEMBL5341184 | 0.79 | FLT1 (0.50) | FLT1FLT4KDRIMPDH2CLK1 | |
| SCHEMBL5318108 | 0.79 | FLT1 (0.50) | FLT1FLT4KDRIMPDH2 | |
| SCHEMBL14466940 | 0.78 | KDR (0.49) | FLT1FLT4KDRIMPDH2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |