Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ARNT | P27540 | 2/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | DDX3X | O00571 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6391336 | 0.89 | CCR2 (0.44) | CRHBPCRHR2NFKBIARELAMEN1 | |
| SCHEMBL5319580 | 0.87 | CRHBP (0.38) | CRHBPCRHR2NFKBIARELAMEN1 | |
| SCHEMBL5284276 | 0.83 | CYP2C9 (0.42) | CRHBPCRHR2NFKBIARELAMEN1 | |
| SCHEMBL6391201 | 0.75 | MEN1 (0.45) | CRHBPCRHR2NFKBIARELAMEN1 | |
| SCHEMBL5246316 | 0.70 | MEN1 (0.49) | CRHBPCRHR2NFKBIARELAMEN1 | |
| SCHEMBL1471553 | 0.69 | CRHBP (0.50) | CRHBPCRHR2MEN1KMT2AHPGD | |
| SCHEMBL1471216 | 0.69 | CYP2C9 (0.47) | CRHBPCRHR2MEN1KMT2AHPGD | |
| SCHEMBL6391130 | 0.68 | POLB (0.48) | MEN1KMT2AHPGDL3MBTL1CCR2 | |
| SCHEMBL1472050 | 0.68 | CCR2 (0.48) | CRHBPCRHR2MEN1KMT2AHPGD | |
| SCHEMBL1471622 | 0.68 | CRHBP (0.51) | CRHBPCRHR2MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758873-A1 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | claimed |