Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 3/20 | 0.55 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 4/20 | 0.41 |
| ▸ | FLT4 | P35916 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318419 | 0.89 | KDR (0.56) | VCPMKNK1ROCK1KIF11IMPDH2 | |
| SCHEMBL14466077 | 0.83 | VCP (0.58) | VCPSIRT7DGAT1ROCK1IMPDH2 | |
| SCHEMBL5318423 | 0.81 | VCP (0.56) | VCPSIRT7P2RX3DGAT1ROCK1 | |
| SCHEMBL14466946 | 0.76 | VCP (0.58) | VCPSIRT7DGAT1IMPDH2FLT1 | |
| SCHEMBL5343891 | 0.76 | VCP (0.58) | VCPSIRT7MKNK1ROCK1IMPDH2 | |
| SCHEMBL5338652 | 0.76 | VCP (0.58) | VCPSIRT7DGAT1IMPDH2FLT1 | |
| SCHEMBL5316983 | 0.76 | VCP (0.58) | VCPSIRT7DGAT1IMPDH2FLT1 | |
| SCHEMBL5340632 | 0.76 | VCP (0.58) | VCPSIRT7DGAT1ROCK1IMPDH2 | |
| SCHEMBL5316977 | 0.76 | VCP (0.55) | VCPSIRT7P2RX3DGAT1PIK3CG | |
| SCHEMBL5317806 | 0.75 | VCP (0.54) | VCPSIRT7PGRDGAT1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |