Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 2/20 | 0.57 |
| ▸ | FLT4 | P35916 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | IGF1R | P08069 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 12/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5344443 | 0.89 | KDR (0.59) | FLT1FLT4KDRIGF1RMAOB | |
| SCHEMBL5433991 | 0.87 | RAF1 (0.52) | FLT1FLT4KDRIGF1RMAOB | |
| SCHEMBL5344457 | 0.85 | IGF1R (0.50) | FLT1FLT4KDRIGF1RMAOB | |
| SCHEMBL5334189 | 0.85 | FLT1 (0.52) | FLT1FLT4KDRIGF1RMAOB | |
| SCHEMBL5336694 | 0.85 | FLT1 (0.52) | FLT1FLT4KDRIGF1RMAOB | |
| SCHEMBL5318416 | 0.85 | TNIK (0.60) | FLT1FLT4KDRRETIMPDH2 | |
| SCHEMBL5338278 | 0.85 | KDR (0.51) | FLT1FLT4KDRIGF1RMAOB | |
| SCHEMBL5341184 | 0.83 | FLT1 (0.50) | FLT1FLT4KDRIGF1RMAOB | |
| SCHEMBL5318108 | 0.83 | FLT1 (0.50) | FLT1FLT4KDRIGF1RMAOB | |
| SCHEMBL5316855 | 0.83 | VCP (0.62) | FLT1FLT4KDRIGF1RRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |