Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319152 | 0.99 | CA1 (0.57) | CA1CA2HDAC6HDAC1HDAC10 | |
| SCHEMBL5340406 | 0.99 | CA1 (0.57) | CA1CA2HDAC6HDAC1HDAC10 | |
| SCHEMBL14467239 | 0.99 | CA1 (0.57) | CA1CA2HDAC6HDAC1HDAC10 | |
| SCHEMBL5319783 | 0.88 | PTGS1 (0.48) | CA1CA2HDAC6HDAC1HDAC10 | |
| SCHEMBL5318871 | 0.88 | PTGS1 (0.48) | CA1CA2HDAC6HDAC1HDAC10 | |
| SCHEMBL5322648 | 0.86 | PTPN1 (0.51) | HDAC6HDAC1HDAC10KDM4EMEN1 | |
| SCHEMBL14467238 | 0.84 | CA1 (0.59) | CA1CA2HDAC6HDAC1HDAC10 | |
| SCHEMBL5344606 | 0.80 | HDAC1 (0.53) | HDAC6HDAC1HDAC10ALDH1A1PTPRC | |
| SCHEMBL4106593 | 0.77 | PTPN1 (0.49) | HDAC6HDAC1KDM4EALDH1A1PTPRC | |
| SCHEMBL5988010 | 0.77 | PTPN1 (0.49) | HDAC6HDAC1KDM4EALDH1A1PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081755-A2 | INDOLE-BENZIMIDAZOLE AND INDAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | METABASIS THERAPEUTICS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |