Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5349010 | 0.86 | CCR2 (0.55) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5318246 | 0.84 | CCR2 (0.70) | CCR2 | |
| SCHEMBL5320145 | 0.83 | CCR2 (1.00) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5946961 | 0.83 | CCR2 (1.00) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5327765 | 0.83 | CCR2 (0.56) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5357090 | 0.79 | CCR2 (0.53) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5947236 | 0.78 | CCR2 (1.00) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL17385570 | 0.78 | CCR2 (1.00) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5947353 | 0.78 | CCR2 (1.00) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL17385571 | 0.78 | CCR2 (1.00) | CCR2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802602-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-04 | — | — | EP | claimed |
| WO-2006036527-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-06 | — | — | WO | claimed |