Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5321020 | 0.86 | RAB9A (0.52) | MAPTTP53RAB9AHPGDALDH1A1 | |
| SCHEMBL5319593 | 0.83 | RAB9A (0.49) | MAPTTP53RAB9AHPGDKDM4E | |
| SCHEMBL1095704 | 0.79 | MAPT (0.58) | MAPTTP53RAB9AHPGDALDH1A1 | |
| SCHEMBL1105403 | 0.79 | MAPT (0.58) | MAPTTP53RAB9AHPGDALDH1A1 | |
| SCHEMBL5317978 | 0.78 | MAPT (0.59) | MAPTTP53RAB9AHPGDALDH1A1 | |
| SCHEMBL4772394 | 0.75 | RAB9A (0.65) | MAPTTP53RAB9AHPGDALDH1A1 | |
| SCHEMBL18117673 | 0.75 | MAPT (0.60) | MAPTTP53RAB9AHPGDALDH1A1 | |
| SCHEMBL10940888 | 0.74 | HPGD (0.74) | MAPTTP53RAB9AHPGDALDH1A1 | |
| SCHEMBL15786285 | 0.72 | MAPT (0.66) | MAPTTP53RAB9AHPGDALDH1A1 | |
| SCHEMBL1094546 | 0.72 | PIK3CG (0.52) | ALDH1A1KDM4ELMNAEGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081630-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-19 | — | — | WO | claimed |
| WO-2007081630-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-19 | — | — | WO | disclosed |