Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 18/20 | 0.73 |
| ▸ | MAOA | P21397 | 2/20 | 0.61 |
| ▸ | MAOB | P27338 | 2/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5320406 | 1.00 | ACHE (0.73) | ACHEMAOAMAOBBCHE | |
| SCHEMBL5319130 | 0.94 | ACHE (0.82) | ACHEMAOAMAOBBCHE | |
| Fumaric Acid SCHEMBL3301189 | 0.92 | ACHE (0.62) | ACHEMAOAMAOBBCHE | |
| SCHEMBL5319127 | 0.86 | ACHE (0.69) | ACHEMAOAMAOBBCHE | |
| SCHEMBL3298374 | 0.86 | ACHE (0.98) | ACHEMAOAMAOBBCHE | |
| SCHEMBL3298383 | 0.86 | ACHE (0.98) | ACHEMAOAMAOBBCHE | |
| Fumaric Acid SCHEMBL3304335 | 0.85 | ACHE (0.66) | ACHEMAOAMAOBBCHE | |
| Fumaric Acid SCHEMBL3304339 | 0.85 | ACHE (0.66) | ACHEMAOAMAOBBCHE | |
| Hydrochloric Acid SCHEMBL3299640 | 0.85 | ACHE (1.00) | ACHEMAOAMAOBBCHE | |
| Fumaric Acid SCHEMBL3301186 | 0.84 | ACHE (0.74) | ACHEMAOAMAOBBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007100583-A2 | PROPARGYLATED AMINOINDANS, PROCESSES FOR PREPARATION, AND USES THEREOF | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2007-09-07 | — | — | WO | disclosed |